MovDisordV3, Main, Exploration, bibRecord, 000474

Plasma melatonin is reduced in Huntington's disease.

Identifieur interne : 000474 ( Main/Exploration ); précédent : 000473; suivant : 000475

Plasma melatonin is reduced in Huntington's disease.

Auteurs : Eirini Kalliolia [Royaume-Uni] ; Edina Silajdži ; Rajasree Nambron ; Nathan R. Hill ; Anisha Doshi ; Chris Frost ; Hilary Watt ; Peter Hindmarsh ; Maria Björkqvist ; Thomas T. Warner

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:25164424

English descriptors

KwdEn :
- Adult, Aged, Female, Fourier Analysis, Humans, Huntington Disease (blood), Male, Melatonin (blood), Middle Aged, Severity of Illness Index.
MESH :
- chemical , blood : Melatonin.
- blood : Huntington Disease.
- Adult, Aged, Female, Fourier Analysis, Humans, Male, Middle Aged, Severity of Illness Index.

Abstract

This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced in stage II/III Huntington's disease subjects compared with controls. We also observed a nonsignificant trend toward reduced mean and acrophase melatonin in premanifest Huntington's disease subjects. Onset of melatonin rise was significantly more temporally spread in both premanifest and stage II/III Huntington's disease subjects compared with controls. A nonsignificant trend also was seen for reduced pulsatile secretion of melatonin. Melatonin concentrations are reduced in Huntington's disease. Altered melatonin patterns may provide an explanation for disrupted sleep and circadian behavior in Huntington's disease, and represent a biomarker for disease state. Melatonin therapy may help the sleep disorders seen in Huntington's disease.

DOI: 10.1002/mds.26003
PubMed: 25164424

Affiliations:

Le document en format XML

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<author><name sortKey="Doshi, Anisha" sort="Doshi, Anisha" uniqKey="Doshi A" first="Anisha" last="Doshi">Anisha Doshi</name>
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<front><div type="abstract" xml:lang="en">This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced in stage II/III Huntington's disease subjects compared with controls. We also observed a nonsignificant trend toward reduced mean and acrophase melatonin in premanifest Huntington's disease subjects. Onset of melatonin rise was significantly more temporally spread in both premanifest and stage II/III Huntington's disease subjects compared with controls. A nonsignificant trend also was seen for reduced pulsatile secretion of melatonin. Melatonin concentrations are reduced in Huntington's disease. Altered melatonin patterns may provide an explanation for disrupted sleep and circadian behavior in Huntington's disease, and represent a biomarker for disease state. Melatonin therapy may help the sleep disorders seen in Huntington's disease.</div>
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Movement Disorders (revue)

Plasma melatonin is reduced in Huntington's disease.

Plasma melatonin is reduced in Huntington's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.